Genomic and Genetic Disorders Biobank
نویسندگان
چکیده
منابع مشابه
Phenotypic variability and genetic susceptibility to genomic disorders.
The duplication architecture of the human genome predisposes our species to recurrent copy number variation and disease. Emerging data suggest that this mechanism of mutation contributes to both common and rare diseases. Two features regarding this form of mutation have emerged. First, common structural polymorphisms create susceptible and protective chromosomal architectures. These structural ...
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Recent technological advances in genetic manipulations and DNA microarrays are profoundly altering the landscape of biological research, offering opportunities to investigate biological questions that were only dreamed of a few years ago. With this revolution comes the hope of being able to tackle some of the more arduous challenges that the central nervous system has presented to the research ...
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Our group uses methods for comparative genome analy sis to study cancer and human genetic disorders. New mutations, somatic and germline, underlie the cancers and human genetic disorders. Our main focus to date has been studying mutations that change the numbers of copies of sections of the genome, causing regions of deletion and duplication, in cancer and pediatric disor ders. Our research i...
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A property analysis of the U.K. Biobank reveals a new imagination of the genomic biobank as a national common-pool resource. U.K. Biobank's treatment of property and governance exhibit both strengths and weaknesses that may be instructive to genome project planners around the world.
متن کاملGenomic Disorders Andduplication
component, it is all the more surprising that the major cause of panic, agoraphobia and related anxiety disorders could lie almost entirely within the human genome (Gratacos et al, 2001). This appears to be because of a bizarre twist in our DNA: an unprecedented common duplication of genetic material on chromosome 15, leading to three instead of two copies of about 60 genes in most cells. This ...
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ژورنال
عنوان ژورنال: Open Journal of Bioresources
سال: 2015
ISSN: 2056-5542
DOI: 10.5334/ojb.ag